Hydroxychloroquine metabolite

Hydroxychloroquine is N-dealkylated by CYP3A4 to the active metabolite desethylhydroxychloroquine, as well as the inactive metabolites desethylchloroquine and bidesethylchloroquine. Therapeutic effects are cumulative; maximum effects may require weeks to months of treatment

2024-03-28
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  1. Hydroxychloroquine
  2. © 2021
  3. 7)
  4. 1985; 344:241-248
  5. 0, 25
  6. N -delakylation(s) (Fig
  7. Abstract
  8. The aim of this study was to measure hydroxychloroquine and its
  9. Chloroquine (CQ) is used to prevent and treat malaria and amebiasis
  10. 0, 25
  11. In vitro, hydroxychloroquine is metabolized mainly by
  12. (6) Polymorphisms in these enzymes may also alter disposition
  13. After
  14. The mean fraction of the dose absorbed was 0